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Oral-delivery of GLP-1 mimetics have been pursued for many years, with semaglutide being the first and only one in the clinic albeit its low bioavailability and frequent gastrointestinal complaints 6,7

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3A shows that all PDR-MNs patches can withstand a force of 50 N, approximately 0.22 N per needle (~225 needles per patch), which is sufficient for MNs to penetrate human skin without damaging the MN structure (threshold insertion force is ~ 13.05 N for a patch of 225 MNs which is ~ 0.058 N per needle) [48, 52]