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10 seconds for Wegovy) before withdrawing the needle Releasing the skin pinch before withdrawing the needle Avoiding massage or rubbing of the injection site immediately after administration Needle considerations may also impact comfort

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Data availability The datasets generated and analysed during the current study are not publicly available due to ethical consideration, but are available from the corresponding author on reasonable request

The NHE3 inhibition mechanism in the renal proximal tubule is a class-wide effect tied to GLP-1 receptor activation