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No drug-related serious AEs, no AEs leading to discontinuation, no death, and no severe hypoglycemia events were reported
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Separately, if tachyphylaxis is a limiting factor for GLP1 agonist therapeutic efficacy, identifying and avoiding molecular events that underpin GLP1 receptor desensitisation and/or downregulation may be a fruitful approach
Szabo G, Iracheta-Vellve A
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