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Purpose of Review: This article summarizes the medical management of obesity with an emphasis on incretin-based therapeutics that target the neuro-hormonal basis of obesity.Recent Findings: Medications that mimic the effect of incretins, a group of peptide hormones released in response to nutrient intake that regulate appetite, result in potent and durable weight loss

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Orforglipron led to greater weight loss than semaglutide tablets and could offer more effective oral alternative to jabs

In the sensitivity analysis, extended maximum treatment duration, types of subsequent treatment following therapy discontinuation, and weight-rebound rates were identified as key drivers for model results

Antibodies and small molecules that interact with incretin targets are also being developed, as well as agents to modulate mitochondrial function, fatty acid receptors and receptors for selected gastrointestinal and adipocyte peptides that affect appetite or pathways of nutrient metabolism