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However, in a murine model, knockout of glucagon genes originating from the bowel elicited no increase in food intake, and thus appetite suppression is attributed to GLP-1 produced within the CNS [112]

Medication Interaction Framework: What Providers Must Evaluate Healthcare providers assessing concurrent use must consider baseline glucose control, prednisone indication and expected duration, tirzepatide efficacy to date, and individual risk factors for steroid-induced hyperglycemia

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Thats the general rule of thumb for adults, according to the National Library of Medicine

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