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In SURMOUNT-1, the percentage of participants hitting these thresholds tells the real story

Patients should be counseled that gastrointestinal symptoms usually do not indicate treatment failure and often resolve with continued therapy

The distinction between cramping and general soreness matters for treatment

No mixing

If you miss three or more doses of tirzepatide consecutively, your healthcare provider may recommend lowering your dosage or restarting the dose escalation process at 5 mg weekly
