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At the same time, careful screening and monitoring remain important, especially for individuals with eating disorders or mood disorders

30 The present data suggest that among patients with MASLD, GLP-1 RAs may offer other survival benefits than those conferred by slowing the risk of liver disease progression

Semaglutide also suppresses the secretion of glucagon, another hormone produced by the pancreas that typically raises blood glucose levels

Some patients benefit from slower titration schedules, microdose protocols, or switching to a dual-compound approach with tirzepatide to bypass tolerance barriers and achieve meaningful weight loss

[DOI] [PubMed] [Google Scholar] 118.Kosiborod MN, Deanfield J, Pratley R, et al

Individuals with a history of depression, bipolar disorder, or suicide attempts should discuss semaglutide risk with their mental health provider before starting treatment
