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Abstract Nonalcoholic fatty liver disease (NAFLD) is a prevalent metabolic liver disease closely associated with the epidemics of obesity and type 2 diabetes mellitus (T2DM), but without licensed pharmacological treatment to date

Results from observational and retrospective studies must be interpreted with caution and can only establish associations and not causeandeffect relationships, which is an inherent limitation to the administrative nature of data or retrospective study design

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Improved glycemic control through enhanced glucose-dependent insulin secretion and reduced glucagon secretion [3]