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Practical Considerations for Clinicians When discussing the potential blood pressure effects of GLP-1 medications with patients, careful framing is essential

73,74 The anti-fibrotic effects of DPP4 inhibitors such as vildagliptin and sitagliptin have been demonstrated in a mouse model of bleomycin-induced skin fibrosis, characterized by improved dermal texture, reduced hydroxyproline content, and decreased myofibroblast deposition through the inhibition of TGF--induced ERK signaling

GLP-1 and GIP Mechanism

No, berberine cannot replace prescription GLP-1 medications as it works through entirely different mechanisms and lacks the extensive clinical evidence, regulatory approval, and proven efficacy of licensed GLP-1 receptor agonists

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Topline results from the ESSENCE trial demonstrated that 62.7% of patients who received once-weekly Wegovy 2.4 mg SC had improved steatohepatitis and 37% had improved liver fibrosis compared 34.1% and 22.5%, respectively, of patients who received placebo