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Amylin receptor activation in the ventral tegmental area reduces motivated ingestive behavior

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However, GLP1-Rs, due to their ability to escape inactivation by DPP-IV and to cross the BBB, are promising candidates to treat neurodegenerative diseases such as PD

Further, semaglutide demonstrated from experimental evidence that it activated adipocyte browning, mainly on subcutaneous fat adipocytes by improving UCP1, mitochondrial biogenesis and thermogenesis, promoting weight loss

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This was confirmed by their reduction in PHQ-9 score of 17 points and of their GAD-7 score by 7 points, with an associated weight loss of over 11%