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For the cardiovascular risk reduction indication, some Medicare Advantage plans may cover Wegovy following the 2024 CMS guidance

Most obesity medicine specialists consider the risk-benefit ratio unfavorable when safer, evidence-based alternatives exist

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Clinical trials of GLP1 and GIP/GLP1 therapies show meaningful total weight loss, but a slice of that loss comes from fatfree mass (which includes muscle, bone and body water) (Jendle et al., 2022)

Surgical-Level Durability: In the extended 104-week tracking arm for severe obesity, weight loss continued downward without a plateau , maxing out at an astonishing 30.3% mean weight loss (an average of 85 pounds dropped)