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What Doctors and Experts Say The Gallup data also captured an important nuance: 19 percent of current GLP-1 users are taking compounded versions formulations not approved by the FDA that became widely available during supply shortages

The glucagon receptor agonism is particularly notable because glucagon increases energy expenditure, promotes hepatic fatty acid oxidation and ketogenesis, and enhances lipolysis primarily in adipose tissue effects that may amplify overall weight reduction beyond what GLP-1 or GIP activation alone can achieve

and (3) real-world sales via telehealth/online channels are underreported in the topline numbers analysts track, so the "slowdown" may be partly a data-visibility problem, not a demand problem