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Health Canada is warning people not to buy or use fake or unauthorized versions of GLP-1 drugs such as semaglutide, the active ingredient in Ozempic and Wegovy

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We also address current barriers to implementation and evidence-based use, ongoing clinical trials, and future directions, including combination therapies that may enhance efficacy and patient outcomes.

It details preclinical and clinical evidence linking GLP-1 receptor activation to cardiovascular, renal, hepatic, neural, and joint anti-inflammatory effects while outlining uncertainties and future research needs.