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doi: 10.1177/17474930221135983 54 YaoMRenYJiaYXuJWangYZouKet al

GLP-1RAs inhibit RGC apoptosis in glaucoma through GABAergic signaling, but their role in AMD, characterized by oxidative stress and choroidal neovascularization, needs further investigation ( The latest diabetic retinopathy preferred practice guidelines from the American Academy of Ophthalmology indicate that the rising use of GLP-1RAs may lead to quick glycemic control and severe hypoglycemia and has been reported to cause higher rates of retinopathy complications, especially in patients with early-stage DR ( 4.2 Delivery optimization Systemic administration of GLP-1RAs reduces their availability in the retina and can lead to off-target effects, particularly gastrointestinal issues

Tirzepatide is FDA-approved for adults with obesity (a BMI of 30 or more) or adults with overweight (BMI of 27 or more) who also have related health issues such as high blood pressure, obstructive sleep apnea, or type 2 diabetes

Dulaglutide offers another long-acting option, while Tirzepatide combines GIP and GLP-1 activity in a way that may enhance both weight management and glucose control