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For tirzepatide versus semaglutide, contrary to the primary endpoint in the head-to-head comparison, there was some supporting evidence for tirzepatide to have a modest benefit, although the 95% CI overlapped the null (HR 0.91, 95% CI 0.81 to 1.01) (Fig

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This design grants it an extended duration of action, allowing for a once-weekly dosing regimen in humans

Pancreatic enzyme elevations may be slightly more pronounced with tirzepatide due to the dual receptor mechanism, though clinically significant pancreatitis remains equally rare with both