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GLP-1: glucagon-like peptide 1 receptor

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Step therapy can be waived with documented intolerance to phentermine, prior failure to lose weight on phentermine, or contraindication (cardiovascular disease, uncontrolled hypertension, seizure history)

Efficacy of once-weekly tirzepatide versus once-daily insulin degludec on glycaemic control measured by continuous glucose monitoring in adults with type 2 diabetes (SURPASS-3 CGM): A substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial

Our previous work concluded that this was a consequence of glucagon deficiency rather than improved insulin sensitivity or secretion, as determined by a hyperinsulinaemiceuglycaemic clamp and an IVGTT [9]