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All individuals were unique users and had not received any of the three medications prior

Aklhaled and Butsch are with the Cleveland Clinic Foundation in Cleveland, Ohio

April Hines has battled with her weight since she was a teenager

Do not think in terms of "days" as abstract concepts

The most commonly reported side effects were gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, which were generally mild to moderate and most frequent during the dose-escalation phase

Meet our doctors Last reviewed: 19 Jun 2026 Sources Glucagon-like peptide-1 (GLP-1): a gut hormone of potential interest in the treatment of diabetes (1998) PubMed [accessed 21 October 2025] Wegovy dosing schedule (2024) Wegovy.com [accessed 21 October 2025] Wegovy (semaglutide): a new weight loss drug for chronic weight management (2022) BMJ [accessed 21 October 2025] Wegovy 0.25 mg, FlexTouch solution for injection in pre-filled pen (2023) EMC [accessed 13 January 2026] Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes, The New England Journal of Medicine [accessed 21 October 2025] Weight loss injections NHS weight loss injections GLP-1 for weight loss Can doctors help with weight loss