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In the Phase 2 clinical trial, obese patients treated with a 12-milligram dose for 48 weeks experienced an average weight reduction of 24.2% (approximately 58 pounds/26.2 kilograms), significantly better than the 2.1% reduction in the placebo group

(2005) Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and down-regulation of bax expression

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Opt for meals rich in fibre and low in calories to maximise GLP-1 efficacy

They work on overlapping receptors

The pre-treatment assessment should include a detailed medical history covering cardiovascular disease, diabetes, thyroid disorders, gallbladder disease, pancreatitis, and previous weight loss attempts