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Yes, semaglutide can go bad in several ways : If passed its expiration date

N Engl J Med 2015;373:1122.ArticlePubMed 9

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The medication doesn't block sugar taste buds or prevent you from eating sweetsinstead, it dampens the reward signals your brain receives from sugar

The medication works by slowing gastric emptying, which helps you feel fuller for longer, and by acting on areas of the brain that regulate appetite

Body composition changes on this protocol follow a somewhat predictable pattern, though individual variation is substantial