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The study further indicated that depression or anxiety decreased with increasing duration of treatment after the initiation of GLP-1 RA medication

Since GLP-1 inhibitors have a half-life of about five weeks, it can take a few months for them to be fully cleared

Semaglutide vs Zovaglutide: Weekly vs Monthly GLP-1 Agonists Evidence-based comparison of semaglutide (Wegovy/Ozempic) and zovaglutide (QL Biopharm), examining weekly vs monthly GLP-1 dosing frequency, STEP vs Phase 2 data, and the clinical implications of once-monthly injection

The safest protocol is to discontinue phentermine under medical supervisiontypically over 1-2 weeksand then initiate semaglutide after a wash-out period

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Nevertheless, GLP-1 presented a rather ephemeral circulatory half-life, lasting a mere 12 min, due to the rapid enzymatic degradation by dipeptidyl peptidase IV (DPP-4), which markedly limits its biological efficacy [3,4,5]