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By contrast, participants receiving placebo lost an average of only 2.6% of their body weight

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Interestingly, increases in plasma GLP-1 in GE2-treated rats were observed only in females

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Moreover, it has recently been reported that metformin inhibits the apical sodium-dependent bile acid transporter and thus may increase the concentration of bile acids in the intestine [12], which could stimulate GLP-1 secretion from L cells via the G-protein-coupled receptor TGR5 [13]

[DOI] [PubMed] [Google Scholar] 472.Fehmann H.C., Goke B., Goke R., Trautmann M.E., Arnold R