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Mutations in KRAS are an early oncogenic event in pancreatic cancer and are thought to be an initiating event [32]

However, in A Diabetes Outcome Progression Trial (ADOPT), metformin exhibited a reduced risk of monotherapy failure compared with the sulfonylurea glibenclamide (known as glyburide in the USA and Canada) and slower rate of loss of beta cell function, although it was inferior to the thiazolidinedione rosiglitazone [20]

Danne T, Biester T, Kapitzke K, Jacobsen SH, Jacobsen LV, Petri KCC, et al

After those were introduced, studies began to suggest they, too, had benefits which extended beyond their use in preventing heart attacks and strokes, such as lowering the risk of some types of cancer and perhaps protecting the brain from dementia