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To find out more go to: To view or add a comment, sign in Obesity and the Gut Microbiome: Moving Beyond the Energy Balance Paradigm The pathophysiology of obesity extends far beyond the traditional concept of caloric intake versus energy expenditure

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For instance, an observational study showed complete remission of T2DM inversely correlated with duration of diabetes, with remission rates highest in those with a more recent diagnosis [34]

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Here, we longitudinally profiled hepatic disease stages in GAN DIO-NASH mice, a translational model widely used in preclinical research and drug discovery for NASH 18,19,20