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These substitutions preserve receptor affinity while enabling pharmaceutical-grade solubility

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In clinical trials, non-diabetic individuals taking semaglutide experienced significant weight loss, with average weight loss ranging from 10% to 15% of initial body weight over 6-12 months of treatment

The secondary outcomes were all-cause death, heart failure admission, admission due to any cause, composite major adverse limb events including newly diagnosed peripheral arterial disease, claudication, clinical limb ischemia, limb revascularization or amputation, hypoglycemia, diabetic ketoacidosis (DKA) or hyperosmolar hyperglycemic state (HHS), and infection death

The results of the study showed that semaglutide consistently induced greater weight loss compared to comparators across all trials, irrespective of baseline BMI