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CAEs were then filtered and grouped into the reason for use in the following groups: T2DM, weight management (WM), and T2DM+WM

Since brain GLP-1R signaling is to a large extent directly triggered by its peripheral secretion from the intestines via vagal stimulation of the NTS neurons, it seems plausible that proper balance in gut microbiota abundance and diversity can influence action of this peptide in the central nervous system

These findings confirm what we see every day in our patient outcomes

More studies are required to understand whether and how exogenous cannabis administration, as well as different components of the endocannabinoid system, may have direct and/or indirect influences on the GLP-1 system

Procedures such as sleeve gastrectomy and Roux-en-Y gastric bypass produce average weight reductions of 25 to 35% and remain the most durable interventions available for severe obesity and obesity-related metabolic disease

Coleman CI, Limone B, Sobieraj DM, et al