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Since the GLP-1 hormone acts directly on the stomach muscles by reducing the rate of gastric contractions, Wegovys amplified dose has caused individuals to experience a pronounced slowing of gastric emptying, which has caused severe gastroparesis side effects

10.1073/pnas.1411413111 165

Collectively, in the end, GLP-1RAs exasperate the primary cause of obesity: Metabolic Syndrome

Clinicians should not discard a reduction in the GLP-1 RA dose upon a worsening of symptoms (Figure 4) [35]

Holt MK, et al