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The fat loss data is real, and the metabolic benefits are significant

PRLR knockout (Prlr-) mice developed impaired glucose tolerance, decreased insulin secretion, a 20-35% reduction in islet insulin granules, reduced islet density and reduced -cell mass

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Clinical trials evaluating semaglutide for weight management, including the pivotal STEP (Semaglutide Treatment Effect in People with obesity) programme published in the New England Journal of Medicine (2021), did not demonstrate a statistically significant increase in UTI incidence compared to placebo groups