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Furthermore, the robust positive data emerging from trials in OSA, HFpEF, and MASH highlight its transformative potential

Nat Metab 2024;6:290303

To increase the plasma half-life by avoiding renal elimination, GLP-1 analogs were modified by adding acyl groups (liraglutide and semaglutide) or large molecules such as albumin (albiglutide) and the Fc portion of IgG (dulaglutide)

Our research has demonstrated that intraperitoneal administration of Exendin-4 can enhance GLP-1-mediated neural repair in the BLA brain regions

But there are a couple of workarounds that the compounding pharmacies might try to keep selling the copycat drugs, Azar noted

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