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15 likewise, lixisenatide was withdrawn from the US market as of January 1, 2023, for commercial reasons, rather than because of any safety or efficacy issues

GLP-1 also delays gastric emptying, increases satiety, and reduces appetite

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[DOI] [PubMed] [Google Scholar] [142].Ahren B, Leguizamo Dimas A, Miossec P, Saubadu S, Aronson R, Efficacy and safety of lixisenatide once-daily morning or evening injections in type 2 diabetes inadequately controlled on metformin (GetGoal-M), Diabetes care, 36 (2013) 25432550

Accordingly, the American Diabetes Association recommends the use of GLP-1RAs with or without metformin in patients with atherosclerotic cardiovascular disease (ASCVD), chronic kidney disease (CKD), and/or heart failure (HF) [25]

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