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After discontinuing its internal GLP-1 in May of 2025 for causing liver issues, Pfizer won a bidding war against seven other companies for Metsera, which is developing a variety of incretin assets, paying $10 billion in one of 2025s largest M&A deals

Several studies show that metformin can increase plasma active GLP-1 level through enhancing GLP-1 secretion from intestinal L cells 21 or inhibiting dipeptidyl peptidase 4-mediated GLP-1 degradation 22,23

Retrieved March 10, 2026, from 5 Emmerich, S

GIP was one of many intestinal hormones scientists had uncovered by now

Vasan, R