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The FDA has emphasized that compounded drugs may carry risks, including variability in potency and purity

Patients taking GLP-1 receptor agonists had a 1.15 HR of developing NAION compared to control

[DOI] [PMC free article] [PubMed] [Google Scholar] 15.Melson E, Ashraf U, Papamargaritis D, Davies MJ

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The reduced caloric deficit (300-500 calories versus 800 calories with higher doses) results in more gradual but sustainable weight management

Importantly, despite the evidence for use of SGLT-2 inhibitors for DKD treatment, they should not be used in patients with type 1 diabetes because of the risk of euglycaemic diabetic ketoacidosis