what do glp 1 agonists do Why are GLP-1 being used to treat patients with nonalcoholic fatty liver disease? Can one drug do it

There is evidence from in vitro and in vivo studies that GLP-1R activation might have neuroprotective and anti-inflammatory properties by reducing the inflammatory response

GLP-1 Secretion While GLP-1 secretion was originally described in response to glucose, it also occurs with ingestion of a mixed meal and the GLP-1 response is greater than to glucose alone indicating synergy in the stimulation by fat and protein along with glucose (1, 78, 132)

Mazdutide: A Dual GLP-1/Glucagon Receptor Agonist in Early Clinical Evidence Mazdutide (IBI362) is a novel dual GLP-1 and glucagon receptor agonist designed to integrate appetite suppression with increased energy expenditure

Another phase II trial by Sanyal et al

In 1967 Steiner showed that insulin was synthesised from a precursor protein, called proinsulin

Nutrients 15 (24), 5096