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Description
The high-resolution cryo-EM maps of the compound 2GLP-1GLP-1RG s and compound 2LY3502970GLP-1RG s complexes provide a good opportunity to further investigate compound 2-associated positive allosterism 25
In contrast, the pharmacological nanomolar concentrations of GLP-1RAs predominantly activate the cAMP/PKA pathway, potentially explaining their broader therapeutic effects [122]
, Pagani, J
doi: 10.1210/en.2014-1717
L.KennedyN
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