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There are no approved generic versions of semaglutide, according to the FDA

A study led by Harvard T.H

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[1] [2] According to the FDA prescribing information for these medications, changes in urine odor are not listed as a direct adverse effect of semaglutide, though some patients have anecdotally reported noticing differences in their urine smell during treatment

You might also experience vomiting, diarrhea, or constipation

Since grapefruit does not affect these proteolytic enzymes, it does not change how your body processes the medication