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Microdosing GLP-1s sounds great in theory

In the SUSTAIN trials, semaglutide-treated patients achieved mean weight reductions of 10-15% of baseline body weight, with some reaching 20%+ loss at higher doses

Several factors may explain why CVOTs have not demonstrated more robust or statistically significant results with combination therapy

So, Are GLP-1s Ever a Good Option

This effect is thought to involve inhibition of dopamine neuron activity in the ventral tegmental area, a key brain region in the reward system [21, 22]

This study included a 28-week open-label long-term extension in which patients in both treatment groups received BYDUREON 2 mg given subcutaneously once weekly after the 24-week controlled period