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TCF7L2 is a possible regulator of GLP-1 receptor expression in human vascular cells Since there was correlation between the expression levels of GLP-1 receptor and TCF7L2 in the aorta in our experiments and it is well known that TCF7L2 is a transcriptional factor of GLP-1 receptor in pancreatic -cells, we hypothesized that TCF7L2 regulates GLP-1 receptor expression in human vascular cells as observed in -cells

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As corroborated by upregulation of the proteasomal degradation pathway that is responsible for respirasome homeostasis, they likely indicate increased turnover of the respiratory machinery