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Abstract The introduction of the highly potent incretin receptor agonists semaglutide and tirzepatide has marked a new era in the treatment of type 2 diabetes and obesity

Moreover, upon the stimulation of keratinocyte cell suspensions from these patients with TNF and IFN, there was no GLP-1R expression detected, indicating that the expression of GLP1R in psoriatic plaques was from immune cells expressing these receptors

Additionally, questions exist about potential effects in this population, including the impact of rapid weight loss on skin elasticity and lymphatic function in areas already affected by tissue changes

GLP-1 medications for weight loss (with and without diabetes) While GLP-1 medications were originally developed to treat type 2 diabetes, it has become clear that their effects on appetite regulation and satiety can lead to substantial weight loss even in people who do not have diabetes

The medications work by mimicking the gut hormone GLP-1, making patients feel fuller and limiting appetite

Although liraglutide treatment led to a decrease in pro-inflammatory microbial species (e.g., EscherichiaShigella, Megamonas , and Bacillus ) in DM2 patients, no statistically significant differences were observed when compared to metformin treatment