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Molecular and Cellular Endocrinology, 335(1), 2-13

This new medicine, generically called orforgipron, is a big win for Eli Lilly, potentially unlocking a worldwide market of millions more patients who want the convenience of a daily pill they can slot into their existing medicine regimen, at any hour of the day

The pill means no needles, no refrigeration, and daily dosing from $149 per month, but requires a strict morning fasting rule

This finding may relate to the different abilities of these agonists to target brain regions that are crucial for memory processes (Salinas et al., 2018)

doi: 10.3389/fendo.2021.803363 47

A 2022 review in Gastroenterology looked at GLP-1 agonist use across multiple trials and found a roughly two-fold increase in acute pancreatitis risk compared to placebo