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This is conferred by a targeted amino acid substitution at the 8th position, replacing alanine with glutamic acid, a modification also found in exenatide-based GLP-1 therapies

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No head-to-head clinical trials comparing the two routes exist, but provider-reported outcomes and user experiences suggest similar weight loss trajectories when dosing is properly calibrated

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( Further reading: Where to buy retatrutide in the UK) In the TRIUMPH-1 Phase 3 trial, the most common retatrutide side effects were nausea, diarrhoea, constipation and vomiting

GLP-1 receptor agonists like semaglutide mimic the effects of GLP-1, a hormone that is released after meals to signal satiety and reduce food intake