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Through its unique mechanism of action as a glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, as well as its impressive results in clinical trials, tirzepatide has the potential to completely transform the current approach to treating obesity

AggregatesResidue deletion peptides, partial deprotections, and sequence isomers usually represent the significant classes of impurities immediately after solid-phase peptide synthesis (SPPS) or the "crude" stage

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The rate of metabolic bariatric surgery decreased from 2022 to 2023, whereas the use of GLP-1 receptor agonists as anti-obesity medications grew over twofold, a research letter showed