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Specifically, GLP-1 RAs showed significantly reduced risks of progression to systolic heart failure (HR 0.60) and stroke (HR 0.75) compared to SGLT2 inhibitors

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After a few years of injectable dominance, oral formulations are emerging as a game-changer for adherence and ease of use thanks to their lack of cold-chain requirement, but also a game-changer for their ability to unlock the long-term maintenance opportunity [14]

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Conclusion Semaglutide reduced the risk of MACE vs comparators across the continuum of baseline CV risk in a broad T2D population

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