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Good prescribers discuss ranges, set realistic expectations, and emphasize that results depend on medication plus lifestyle modification

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Although preliminary data from 12 patients with sickle cell anemia showed a decrease in PAH, a larger clinical trial (n = 134) investigating the use of sildenafil for pulmonary hypertension in adults with sickle cell anemia was stopped early due to an increased risk of severe adverse effects, especially sickle cell pain crises, compared to placebo (38% vs

This study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline
