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doi: 10.2337/dc09-1499

Thomas DM, Martin CK, Heymsfield S, Redman LM, Schoeller DA, Levine JA

While tirzepatide has demonstrated a generally favorable safety profile in clinical trials, specific considerations apply when treating patients with autoimmune thyroid disease and hypothyroidism

Dysregulation of GLP-1R signaling contributes to impaired insulin secretion, altered lipid homeostasis, hyperglycemia, and metabolic dysfunction observed in obesity and type 2 diabetes [1]

Baseline CRP and TNF- levels were also significantly decreased due to using exenatide in combination with metformin

The Framework was developed with input from people living with diabetes, academics, researchers, not-for-profit organizations, provinces and territories, Indigenous communities, and other key partners to ensure it significantly improves the lives of those with diabetes