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The honest summary: Retatrutide probably does produce modestly greater weight loss than tirzepatide at maximum doses, potentially in the range of 36 percentage points of body weight

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As this research is still in its early stages, many articles called for the addition of large randomized controlled trials, further evidence-based studies, and more primary research to aid in providing guidance for perioperative management on patients taking GLP-1 RAs and to further elucidate the impact of these medications on perioperative risks (Chang et al