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Abnormal (dysbiotic) gut microbiota could account for leaky gut and inflammation in older adults (3, 9), since dysbiotic microbiota can produce metabolites that interact with the hosts intestinal epithelial cells to reduce epithelial barrier proteins like zonulin-1 ( Zo1 ), occludin ( Ocln ), and claudins, resulting in disrupted cell-to-cell connections, which compromises intestinal permeability (10, 11)

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Naltrexone/Bupropion (Contrave) Contrave combines two older medications that work on brain chemistry

This helps lower blood sugar levels and slows digestion, reducing hunger

Velocity Clinical Research, Dallas Velocitys research site in Dallas was founded in 1990 as Dallas Diabetes Research Center and acquired by Velocity in 2022