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Meanwhile, Eli Lilly is advancing orforglipron, the first small-molecule GLP-1 receptor agonist for obesity

A new generation of dual and triple receptor modulators targeting nutrient-stimulated hormone pathways are producing cardiometabolic effects that exceed any previous pharmacotherapy, with weight loss efficacy approaching that of bariatric surgery

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(B) Exogenously administered GLP-1, as the one contained in NAOMs, is readily available in systemic circulation, bypassing portal circulation and the deleterious effects of DPP-4
