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About 5% stopped at the lowest dose, 8% at the mid dose, and 10% at the highest dose, compared to about 3% with placebo

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This new study published in #EHJVSHD suggests that moderatesevere TR is not just a marker of advanced disease, but may also represent a practical barrier to the implementation of GDMT Among 858 patients hospitalized for acute decompensated HFrEF, moderatesevere TR was independently associated with a lower likelihood of reaching 50% of target dose at 1 year for RASi/ARNi and beta-blockers but not MRAs

Food and Drug Administration to treat Type 2 diabetes, but some doctors prescribe the medication "off-label" for weight loss, as is permissible by the U.S

Mody R, Manjelievskaia J, Marchlewicz EH, et al