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In addition to its activity against hyperglycemia, DPP-4i has shown beneficial cardiovascular effects including cardioprotective action, endothelial protection, and an anti-hypertensive effect

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Although tirzepatide has not demonstrated anabolic bone actions in animals, 57 an assessment report from the European Medicine Agency observed trends of decreased P1NP and increased CTX-I levels in people with T2D after 29 days of treatment

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For instance, curcumin can upregulate or downregulate writer and eraser expression, thereby altering m 6 A levels on target mRNAs

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Dardmeh F et al

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