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Orforglipron showed similar gastrointestinal side effects as other GLP-1 drugs, with the most common being diarrhea, nausea, indigestion, and constipation

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In particular, animal models have shown that GLP-1 RAs can reduce necrosis in random-pattern skin flaps [97]

doi: 10.3389/fendo.2012.00141 46 WeiYMojsovS

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"Patients who combine medication with consistent lifestyle changesrather than relying on pharmacology aloneare more likely to achieve and maintain substantial, long-term health improvements." Nutrient intake is another thing to consider when starting GLP-1s