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The 4mg dose resulted in constipation in about 15% of participants, while the 8mg dose showed rates around 18%

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Doctors say theyre most appropriate for people with Type 2 diabetes, and adults with a BMI over 30 or 27 with a condition, including people whove had a heart attack or stroke, peripheral vascular disease, and for sleep apnea, Apovian said

For these patients, the goal of personalization is to prescribe just enough medication to achieve targeted results but not so much that the cure feels worse than the disease

Laxity and fat loss can lead to extra tissue in that area, which is definitely bothersome." Some studies also show that rapid weight loss from GLP-1 medications can lead to a decrease in lean muscle mass